Bacterial initiation factor 2
Template:Short description Script error: No such module "redirect hatnote". Template:Pfam box Bacterial initiation factor-2 is a bacterial initiation factor.[1]
IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNAf binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and Pi, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.
Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.[2]
References
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- ↑ Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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