BOLL
Template:Short description Script error: No such module "other uses". Template:Infobox gene Protein boule-like is a protein that in humans is encoded by the BOLL gene.[1][2][3]
Function
This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2 / M transition in fruitfly but in mice the primary defect is postmeiotic at round spermatid stage.[4] Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3][5]
The boule-like protein appears to be ubiquitously expressed in males of all animal species, except in the most primitive trichoplax.[6]
References
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Further reading
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