BECN1
Template:Short description Template:Cs1 config Template:Infobox gene Beclin-1 is a protein that in humans is encoded by the BECN1 gene.[1][2] Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode.[3] This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.
Role in disease
Beclin-1 plays an important role in tumorigenesis, and neurodegeneration, being implicated in the autophagic programmed cell death.[4] Ovarian cancer with upregulated autophagy has a less aggressive behavior and is more responsive to chemotherapy.[5]
Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of those affected, which causes diminished autophagy which in turn results in increased neuronal cell death.[6]
Interactions
BECN1 has been shown to interact with:
Modulators
- Trehalose
- Trehalose reduces p62/Beclin-1 ratio and increases autophagy in the frontal cortex of ICR mice, possibly by increasing Beclin-1.[10]
References
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Further reading
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