BEACOPP
BEACOPP is a chemotherapy regimen for treatment of Hodgkin lymphoma developed by the German Hodgkin Study Group[1] used for patients in Stages > II or early (IA or IB) with unfavorable risk factors.[2] Patients typically receive treatment in cycles of 21 days with no drugs given on days 15–21.[3] There also exists a more intensive regimen with cycles of 14 days. Usually a course of BEACOPP therapy consists of four, sometimes six to eight cycles, or in combination with ABVD. In some countries BEACOPP still is experimental, in others (e.g. Germany and Austria) it is a standard therapy. In the United States, ABVD (or Stanford V) is generally given instead, because of the possibility of BEACOPP inducing more secondary neoplasias (such as leukemias), although the final results from a clinical trial (GHSG HD14) indicate that "there were no overall differences in treatment-related mortality or secondary malignancies" of BEACOPP relative to ABVD.[2]
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- Twice as many infusion per cycle relative to ABVD;
- Requirement for G-CSF support, which was under patent protection in the US until 2013 (as Neupogen by Amgen),[4]Template:Update needed while that patent protection expired in the EU in 2008;[5]
- Higher likelihood of adverse events requiring hospitalization, such as infection or acute toxicity;
However,Template:Tone inline BEACOPP delivers approximately 7% points success relative to ABVD for early unfavorable Hodgkin lymphoma (as measured five-year freedom from treatment failure)[2] and 12% points greater success relative to ABVD for advanced Hodgkin lymphoma (Stage IIB with risk factors or stages III and IV) as measured by seven-year freedom from treatment failure.[6]
Predecessors of BEACOPP were COPP and (the earliest) MOPP.
Dosing regimen
| Drug | Base BEACOPP | Dose-Escalated BEACOPP | Method | Cycle Day |
|---|---|---|---|---|
| (B)leomycin | 10 mg/m2 | 10 mg/m2 | i.v. push | day 8 |
| (E)toposide | 100 mg/m2 | 200 mg/m2 | i.v. infusion | day 1–3 |
| (A)driamycin (doxorubicin) | 25 mg/m2 | 35 mg/m2 | i.v. push | day 1 |
| (C)yclophosphamide | 650 mg/m2 | 1250 mg/m2 | i.v. infusion | day 1 |
| (O)ncovin=Vincristine | 1.4 mg/m2 (max 2 mg) | 1.4 mg/m2 (max 2 mg) | i.v. infusion | day 8 |
| (P)rocarbazine | 100 mg/m2 | 100 mg/m2 | orally | day 1–7 |
| (P)rednisone | 40 mg/m2 | 40 mg/m2 | orally | day 1–14 |
See also
References
- ↑ German Hodgkin Study Group
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- ↑ See HD14 Redacted Trial Protocol, available at
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