BAPTA
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Template:Chembox image cellTemplate:Chembox image cellTemplate:Chembox AllOtherNamesTemplate:Chembox headerbarTemplate:Chembox IndexlistTemplate:Chembox JmolTemplate:Chembox ChEMBLTemplate:Chembox ECHATemplate:Chembox E numberTemplate:Chembox IUPHAR ligandTemplate:Chembox UNIITemplate:Chembox CompToxTemplate:Chembox headerbarTemplate:Chembox Datapage checkTemplate:Chembox Footer| Template:Longitem | Template:Unbulleted list |
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| Template:Longitem | C22H24N2O10 |
| Molar mass | 476.433 |
| Density | 1.494 g/cm3 |
| Melting point | Template:Chembox CalcTemperatures |
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BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) is an aminopolycarboxylic acid with a high affinity for calcium. It is a white solid. It is used in research to chelate Ca2+, as it behaves similarly to EGTA and EDTA.
Complexation
BAPTA, as its conjugate base, binds calcium ions as a decadentate ligand:
According to X-ray crystallography. the four carboxylates, two amines, and two ether oxygens bind to Ca2+.[1]
There is a range of reported values for the dissociation constant of BAPTA, though 0.2 μM appears consistently.[2] The rate constant for calcium binding is 500 μM−1 s−1.[2] The complexation process of calcium ion to BAPTA can be deconvoluted into three main processes: conformational changes of the glicol linker, nitrogen conjugation and electronic effects changes of the benzene rings.[3]
BAPTA is a component of some fluorescent calcium ion indicators such as Calcium Green and Oregon Green 488 BAPTA-1 and -2 (OGB-1, OGB2). These indicators change their fluorescence intensity and fluorescence lifetime depending on the calcium ion concentration.[4]
See also
References
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