BAMBI
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BMP and activin membrane-bound inhibitor homolog, also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[1][2]
Function
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[1]
References
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Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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