Asteroid body
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An asteroid body is a microscopic finding seen within the giant cells of granulomas in diseases such as sarcoidosis and foreign-body giant cell reactions.[1]
There is controversy about their composition. Traditionally, they were thought to be cytoskeletal elements and to consist primarily of vimentin.[2] However, more recent research suggested that that was incorrect and that they may be composed of lipids arranged into bilayer membranes.[3]
They were also once thought to be related to centrioles,[4] an organelle involved in cell division in eukaryotes.
See also
Additional images
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Micrograph of asteroid bodies in pulmonary sarcoidosis. H&E stain.
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Micrograph of asteroid bodies in pulmonary sarcoidosis. H&E stain.
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Asteroid body in sarcoidosis.
References
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