Apronal
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Apronal (brand name Sedormid), or apronalide, also known as allylisopropylacetylurea or allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the ureide (acylurea) group synthesized in 1926[1] by Hoffmann-La Roche. Though it is not a barbiturate, apronal is similar in structure to the barbiturates (being an open-chain carbamide instead of having a heterocyclic ring).[2] In accordance, it is similar in action to the barbiturates, although considerably milder in comparison (formerly used as a daytime sedative at doses of 1 to 2 grams every 3 to 4 hours).[2] Upon the finding that it caused patients to develop thrombocytopenic purpura, apronal was withdrawn from clinical use.[3]
Medicines with apronal are no longer used except in Japan.[3] Notably Australian Therapeutic Goods Administration issued a safety alert in May 2023 which prohibits the sale, supply and use of Japanese EVE-branded products in Australia[4] due to its dangerous side effects.
See also
References
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- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, "Verfahren zur Darstellung von Ureiden der Dialkylessigsaeuren", issued Script error: No such module "auto date formatter"., assigned to Hoffmann-La RocheScript error: No such module "Check for unknown parameters".
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