Anti-actin antibodies

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File:Antibody.svg
Schematic representation of antibody

Anti-actin antibodies (AAA)[1] are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.

In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage.[2][3]

In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition,[4] the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients.[5]

In gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.[6]

It has also been found as a paraneoplastic syndrome with myelodysplastic syndrome.[7]

References

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