Alimemazine

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Alimemazine (INN), also known as trimeprazine, commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine). It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness.

Despite being structurally related to the molecule chlorpromazine, it is not used as an antipsychotic.

Society and culture

Brand names

Brand names include Nedeltran, Panectyl, Repeltin, Teraligen, Therafene, Theraligene, Theralen, Thegalin, Theralene, Vallergan, Vanectyl, and Temaril.

Use by Country

In the Russian Federation, it is sold under the brand name Teraligen for the treatment of anxiety disorders (including GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses.

Veterinary use

In the United States, the Food and Drug Administration (FDA) has not approved it for human use, and it can only be prescribed by veterinarians.

A novel combination drug that combines alimemazine with prednisolone and sold under the brand name Temaril-P is licensed as an antipruritic and antitussive in dogs. A generic version of the combination trimeprazine/prednisolone was approved by the US Food and Drug Administration (FDA) in June 2024.