Acylfulvene
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Template:Use dmy dates Template:Chembox Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom (Omphalotus olearius).[1] One important acylfulvene, 6-hydroxymethylacylfulvene (irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors.[2] It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation).[3]
References
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- ↑ Anchel, M.; Hervey, A.; Robbins, W. J. Proc. Natl. Acad. Sci. U.S.A. 1950, 36, 300
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- ↑ Woynarowski, Jan M.; Napier, Cheryl; Koester, Steven K.; Chen, Shih-Fong; Troyer, Dean; Chapman, William; Macdonald, John R. Biochemical Pharmacology (1997), 54 (11), 1181-1193 CODEN: BCPCA6; Template:Catalog lookup linkScript error: No such module "check isxn".Script error: No such module "check isxn".Script error: No such module "check isxn".Script error: No such module "check isxn".Script error: No such module "check isxn".Script error: No such module "check isxn".Script error: No such module "check isxn".Script error: No such module "check isxn".Script error: No such module "check isxn".. (Elsevier Science Inc.)
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