Acetonedicarboxylic acid
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| Molar mass | 146.09814 g/mol |
| Density | 1.499 g/cm3 |
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Acetonedicarboxylic acid, 3-oxoglutaric acid or β-ketoglutaric acid is a simple dicarboxylic acid with the formula Template:Chem2. β-Ketoglutarate does not have the biological activity exhibited by α-ketoglutarate.[2]
Preparation
Acetonedicarboxylic acid can also be prepared by decarboxylation of citric acid in fuming sulfuric acid:[3]
Applications
Acetonedicarboxylic acid and its esters such as dimethylacetonedicarboxylate are primarily used as building blocks in the synthesis of heterocyclic rings[4] and in the Weiss–Cook reaction.[5]
Acetonedicarboxylic acid is well known to be used in the Robinson tropinone synthesis.
The presence of β-ketoglutaric acid in human urine is diagnostic for the harmful gut flora such as Candida albicans.[6]
See also
References
- ↑ |ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC 1,3-Acetonedicarboxylic acid{{|bot=InternetArchiveBot |fix-attempted=yes }} at Sigma-Aldrich (safety data sheet)
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- ↑ Schmidt, Michael A, Tired of Being Tired: Overcoming Chronic Fatigue and Low Energy