Abafungin
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Abafungin (INN) is a broad-spectrum arylguanidines-class antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.[1]
Abasol is a topical cream formulation of abafungin by York Pharma.[2]
History
Abafungin was first synthesized at Bayer AG, Leverkusen, Germany. A study of H2-antagonists related to famotidine, resulted in the discovery of its antifungal properties.[3]
Its development seems to have been discontinued in 2009.[4]
Mechanism of action
Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.[3]
In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.[5]
Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.[6]
References
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External links
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