AUP1
Template:Short description Template:Infobox gene Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.[1][2][3]
Function
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.[3]
Interactions
AUP1 has been shown to interact with ITGA2B.[2]
References
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External links
Further reading
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