ARID1B
Template:Short description Template:Cs1 config Template:Infobox gene AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene.[1] ARID1B is a component of the human SWI/SNF chromatin remodeling complex.
Clinical significance
Germline mutations in ARID1B are associated with Coffin–Siris syndrome.[2][3] Somatic mutations in ARID1B are associated with several cancer subtypes, suggesting that it is a tumor suppressor gene.[4][5][6][7]
Interactions
ARID1B has been shown to interact with SMARCA4[8][9] and SMARCA2.[9]
References
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Further reading
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Template:UCSC gene info
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.