APOA1BP
Template:Short description Template:Infobox gene Apolipoprotein A-I-binding protein also known as APOA1BP is a protein that in humans is encoded by the APOA1BP gene.[1] Progressive encephalopathy with brain edema and/or leukoencephalopathy-1 (PEBEL-1), a rare, lethal, neurometabolic disorder, is caused by mutation in NAXE gene (APOA1BP being its former name).[2]
Structure
APOA1BP gene is located on chromosome 1, with its specific location being 1q22. The gene contains 6 exons,[3] 5 introns, and spans 2.5 kb.[1] Expression is ubiquitous across all human tissues, with highest observed in kidney, heart, liver, testis, thyroid gland, adrenal gland.[1] APOA1BP contains Yje_FN domain.[4]
Function
APOA1BP binds to APOA1, APOA2, and high-density lipoprotein (HDL).[1] In addition, APOA1BP appears to play a role in sperm capacitation.[5] It has been demonstrated that APOA1BP is involved in angiogenesis regulation, by accelerating cholesterol efflux from endothelial cells to HDL.[6][7] It is known that zebrafish APOA1BP ortholog Aibp is involved in angiogenesis regulation.[6] The protein was also shown to be involved in atherosclerosis protection.[7]
References
<templatestyles src="Reflist/styles.css" />
- ↑ a b c d Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ a b Script error: No such module "Citation/CS1".
- ↑ a b Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".