ALCAM
Template:Short description Template:Infobox gene CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[1][2] It is also called CD166 (cluster of differentiation 166), MEMD,[3] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.
Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands.Script error: No such module "Unsubst". CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanom--a.[3] CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.Script error: No such module "Unsubst".
Recently, CD166 has also been used as a potential cancer stem cell marker.Script error: No such module "Unsubst".
See also
References
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Further reading
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External links
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