AFF1
Template:Short description Template:Cs1 config Template:Infobox gene AF4/FMR2 family member 1 is a protein that in humans is encoded by the AFF1 gene.[1][2][3][4] At its same location was a record for a separate PBM1 gene, which has since been withdrawn and considered an alias. It was previously known as AF4 (ALL1-fused gene from chromosome 4).[4]
The gene is a member of the AF4/FMR2 (AFF) family, a group of nuclear transcriptional activators which encourage RNA elongation. It is a component of the super elongation complex.[5] It is recognized as a proto-oncogene: chromosomal translocations associated with leukemia can fuse this gene with others like KMT2A, producing an uncontrolled activator protein.[1]
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