ADCYAP1R1

Template:Short description Template:Cs1 config Template:Infobox gene Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC₁, is a protein that in humans is encoded by the ADCYAP1R1 gene.^[1] This receptor binds pituitary adenylate cyclase activating peptide.^[2]^[3]

Function

PAC₁ is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family.^[4] This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.^[1] PAC₁ is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.^[5]^[6]^[7] It is also expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).^[8]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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