ADARB1
Template:Short description Template:Cs1 config Template:Infobox gene Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.[1][2][3] The enzyme is a member of ADAR family.
Function
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an Alu cassette insert and a short or long C-terminal region.[3]
ADARB1 requires the small molecule inositol hexakisphosphate (IP6) for proper function.[4] ADARB1 is an A-to-I RNA-editing enzyme that mostly acts on protein-coding substrates.[5]
See also
- Adenosine deaminase (ADA), an enzyme acting on isolated adenosine
References
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Further reading
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External links
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