ACVR1C
Template:Short description Template:Infobox gene
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules.[1]
ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[2]
Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[1]
References
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