60S ribosomal protein L28
Template:Short description Template:Cs1 config Template:Infobox gene 60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.[1][2][3]
Gene
Alternative splicing of RPL28 leads to multiple transcript variants encoding distinct isoforms. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]
Function
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm.[3]
Clinical significance
Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found.[3]
References
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Further reading
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External links
- Template:UCSC gene info
- PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L28
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