5-MeO-2-TMT
Template:Short description Template:Drugbox
5-Methoxy-2,N,N-trimethyltryptamine (5-MeO-2,N,N-TMT, 5-MeO-TMT), also known as 2-methyl-5-methoxy-N,N-dimethyltryptamine (2-Me-5-MeO-DMT), is a serotonin receptor modulator and psychedelic drug of the tryptamine and 2-alkyltryptamine families.[1][2][3][4][5] It was first synthesized by Alexander Shulgin and reported in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).[1]
Dosage and effects
According to Alexander Shulgin in TiHKAL, 5-MeO-TMT has a dose range of 75 to 150Script error: No such module "String".mg orally and a duration of 5 to 10Script error: No such module "String".hours.[1] It produces effects including sexual stimulation, enhanced orgasm, relaxation, sedation, tingling, sleep disturbances, chills and cold sensations, time dilation, reduced heart rate, reduced respiratory rate, mild nausea, motor incoordination, visual waviness, mild to pronounced closed-eye visuals, emotional lability, crying, body temperature fluctuations, uncomfortableness, gastrointestinal disturbances, and abdominal pain.[1] It has been said that 5-MeO-TMT at a dose of 150Script error: No such module "String".mg is definitely hallucinogenic and can be compared to a moderate 300Script error: No such module "String".mg dose of mescaline.[1]
Pharmacology
| Target | Affinity (Ki, nM) |
|---|---|
| 5-HT1A | 200 |
| 5-HT1B | >10,000 |
| 5-HT1D | 250 |
| 5-HT1E | 1,800 |
| 5-HT1F | ND |
| 5-HT2A | >10,000 (rat) |
| 5-HT2B | ND |
| 5-HT2C | 4,020 (rat) |
| 5-HT3 | ND |
| 5-HT4 | ND |
| 5-HT5A | 10,450 |
| 5-HT6 | 60–80 |
| 5-HT7 | 145 |
| α1A–α2C | ND |
| β1–β3 | ND |
| D1–D5 | >10,000 |
| H1 | >10,000 |
| H2 | ND |
| H3, H4 | >10,000 |
| M1–M5 | >10,000 |
| I1 | ND |
| σ1, σ2 | ND |
| TAAR1 | ND |
| SERT | >10,000 |
| NET | 6,380 |
| DAT | >10,000 |
| Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: [6][2][5] | |
The affinities of 5-MeO-TMT for numerous targets have been reported.[2][5] 2-Methyltryptamines like 5-MeO-TMT show a loss of affinity for the serotonin 5-HT2A receptor but retained affinity for the serotonin 5-HT6 receptor.[3][5][2] It also retains significant affinity for the serotonin 5-HT1A, 5-HT1D, and 5-HT7 receptors.[2][5] In contrast to 5-MeO-DMT, 5-MeO-TMT is orally active, suggesting that the 2-methyl group blocks metabolism by monoamine oxidase (MAO).[1]
See also
- 2-Methyltryptamine (2-MT or 2-Me-T)
- 2-Methyl-N,N-diethyltryptamine (2-Me-DET)
- 2,N,N-Trimethyltryptamine (2,N,N-TMT or 2-Me-DMT)
- 2,α-Dimethyltryptamine (2,α-DMT or 2-Me-αMT)
- 5-Methoxy-7,N,N-trimethyltryptamine (5-MeO-7-TMT or 7-Me-5-MeO-DMT)
- 2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT; 2-Et-5-MeO-DMT)
- BGC20-761 (5-MeO-2-phenyl-DMT)
References
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- ↑ a b c d e f Erowid Online Books : "TIHKAL" - #45 5-MEO-TMT
- ↑ a b c d e Script error: No such module "Citation/CS1".
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External links
- 2-Methyl-5-MeO-DMT - Isomer Design
- 5-MeO-TMT Experience Reports - Erowid
- The Big & Dandy 5-MeO-TMT Thread - Bluelight
- 5-MeO-TMT - TiHKAL - Erowid
- 5-MeO-TMT - TiHKAL - Isomer Design
Template:Psychedelics Template:Serotonin receptor modulators Script error: No such module "Navbox".