4-PPBP
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| MeSH | 4-phenyl-1-(4-phenylbutyl)piperidine |
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| Molar mass | 293.446 g/mol |
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4-PPBP is a neuroprotective cyclic amine which binds to sigma receptors.[1]
4-PPBP decreases neuronal nitric oxide synthase (nNOS) activity and ischemia-evoked nitric oxide (NO) production. 4-PPBP provides neuroprotection; this involves the prevention of ischemia-induced intracellular Ca2+ dysregulation.[2] 4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB). Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB.[3]
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