3,3'-Diindolylmethane
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3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale.[1] It and its parent compound Template:Ndash indole-3-carbinol Template:Ndash are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms.[1][2] DIM is sold as a dietary supplement.[1]
Properties
In vitro, DIM has action as a histone deacetylase inhibitor,[1] specifically against HDAC1, HDAC2, and HDAC3.[3] DIM is a metabolite of indole-3-carbinol. [4]
DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2.[5][6]
A study conducted in 2023 by researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, found that DIM can reduce biofilms responsible for dental plaque and cavities by 90%.[7] since 2025[update]Template:Dated maintenance category (articles)Script error: No such module "Check for unknown parameters"., no clinical trials have been conducted that confirm the effectiveness of DIM in reducing plaque.
See also
- Glucobrassicin, precursor to indole-3-carbinol
- Phytochemicals
References
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External links
- Diindolylmethane Information Resource Center, University of California-Berkeley