2C-T

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2C-T, or 2C-T-1, also known as 4-methylthio-2,5-dimethoxyphenethylamine, is a psychedelic and hallucinogenic drug of the 2C family. It is used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs mescaline and 2C-T-2.

Effects

In TiHKAL, Alexander Shulgin lists a dose range of 60 to 100Template:Nbspmg and a duration of 3 to 5Template:Nbsphours for 2C-T. It produces psychedelic and MDMA-like effects.

Pharmacology

2C-T shows affinity for the serotonin 5-HT₂ receptors and is known to act as an agonist of the serotonin 5-HT_2A and 5-HT_2B receptors. The mechanism that produces 2C-T's hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from serotonin 5-HT_2A receptor activation in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known. 2C-T shows no affinity for the monoamine transporters.

Chemistry

2C-T is in a class of compounds commonly known as phenethylamines, and is the 4-methylthio analogue of 2C-O, a positional isomer of mescaline. It is also the 2C analog of Aleph. The systematic name of the chemical is 2-(2,5-dimethoxy-4-(methylthio)phenyl)ethanamine. The CAS number of 2C-T is 61638-09-3.

Derivatives

A large number of derivatives of 2C-T have been developed and described. These include 2C-T-2, 2C-T-3, 2C-T-4, 2C-T-7, and 2C-T-16, among others.

History

2C-T was first synthesized and studied through a collaboration between David E. Nichols and Alexander Shulgin. It was first described in the scientific literature in 1976.

Society and culture

Popularity

2C-T is almost unknown on the black market although it has rarely been sold by "research chemical" companies. Limited accounts of 2C-T can be found in the book PiHKAL.

Legal status

Canada

As of October 31, 2016; 2C-T is a controlled substance (Schedule III) in Canada.

United States

2C-T is unscheduled and unregulated in the United States; however its close similarity in structure and effects to 2C-T-7 could potentially subject possession and sale of 2C-T to prosecution under the Federal Analog Act. This seems to be the tack the federal government is taking in the wake of the DEA's Operation Web Tryp. A series of court cases in the US involving the prosecution of several online vendors were commenced in 2004 and resulted in a number of convictions.

See also

• CYB-210010
• Substituted methoxyphenethylamine

External links

• 2C-T - Isomer Design
• The Big & Dandy 2C-T Thread - Bluelight
• 2C-T - PiHKAL - Erowid
• 2C-T - PiHKAL - Isomer Design