2-oxoglutarate synthase

Template:Short description Template:Infobox enzyme In enzymology, a 2-oxoglutarate synthase (EC 1.2.7.3) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + CoA + 2 oxidized ferredoxin $\rightleftharpoons$ succinyl-CoA + CO₂ + 2 reduced ferredoxin

The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and oxidized ferredoxin, whereas its 3 products are succinyl-CoA, CO₂, and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating). Other names in common use include 2-ketoglutarate ferredoxin oxidoreductase, 2-oxoglutarate:ferredoxin oxidoreductase, KGOR, 2-oxoglutarate ferredoxin oxidoreductase, and 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating). This enzyme participates in the Citric acid cycle. Some forms catalyze the reverse reaction within the Reverse Krebs cycle, as a means of carbon fixation.

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