2-alkenal reductase

Template:Short description Template:Infobox enzyme In enzymology, a 2-alkenal reductase (EC 1.3.1.74) is an enzyme that catalyzes the chemical reaction

n-alkanal + NAD(P)+ $\rightleftharpoons$ alk-2-enal + NAD(P)H + H⁺

The 3 substrates of this enzyme are n-alkanal, NAD⁺, and NADP⁺, whereas its 4 products are alk-2-enal, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.

Structural studies

As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes 2DM6, 2J3J, and 2J3K.

References

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