View source for Haloperidol decanoate

{{Short description|Typical antipsychotic medication}}
{{Drugbox
| Verifiedfields = 
| Watchedfields = 
| verifiedrevid = 
| IUPAC_name = [4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] decanoate
| image = Haloperidol decanoate.svg
| width = 250px

<!--Clinical data-->
| tradename = Halomonth, Haldol Decanoate, Haldol Decanoas, Haloperidol Decanoate, Haloperidol Decanoat, Neoperidole, Serenase Dekanoat
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = 
| legal_UK = 
| legal_US = Rx-only
| legal_status = 
| routes_of_administration = [[Intramuscular injection]]
| class = [[Typical antipsychotic]]

<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion =

<!-- Identifiers -->
| CAS_number_Ref = 
| CAS_number = 74050-97-8
| CAS_supplemental = <br />77129-05-6
| ATC_prefix = 
| ATC_suffix = 
| ATC_supplemental = 
| PubChem = 52919
| IUPHAR_ligand = 
| DrugBank_Ref = 
| DrugBank = DBSALT001195
| ChemSpiderID_Ref = 
| ChemSpiderID = 47814
| UNII = AC20PJ4101
| KEGG = D01898
| ChEBI = 31664
| ChEMBL = 1200986
| synonyms = KD-136; R-13672

<!--Chemical data-->
| C=31 | H=41 | Cl=1 | F=1 | N=1 | O=3
| SMILES = CCCCCCCCCC(=O)OC1(CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F)C3=CC=C(C=C3)Cl
| StdInChI_Ref = 
| StdInChI = 1S/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3
| StdInChIKey_Ref = 
| StdInChIKey = GUTXTARXLVFHDK-UHFFFAOYSA-N
}}

'''Haloperidol decanoate''', sold under the brand name '''Haldol Decanoate''' among others, is a [[typical antipsychotic]] which is used in the treatment of [[schizophrenia]].<ref name="Elks2014">{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA619|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=619–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA509|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=509–}}</ref><ref name="KleemannEngel2014">{{cite book| vauthors = Kleemann A, Engel J, Kutscher B, Reichert D | chapter = Haloperidol decanoate |title=Pharmaceutical Substances: Syntheses, Patents and Applications of the most relevant APIs |edition=5th |date=2009 | chapter-url = https://books.google.com/books?id=fO2IAwAAQBAJ&pg=PT1376 |publisher=Thieme |isbn=978-3-13-179525-0 |pages=1376–}}</ref><ref name="MortonHall2012">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA139|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=139–}}</ref> It is administered by [[intramuscular injection|injection into muscle]] at a dose of 100 to 200&nbsp;mg once every 4&nbsp;weeks or monthly.<ref name="PagliaroPagliaro1999">{{cite book| vauthors = Pagliaro LA, Pagliaro AM |title=Psychologists' Psychotropic Drug Reference|url=https://books.google.com/books?id=n2e2aAYnZYkC&pg=PA260|year=1999|publisher=Psychology Press|isbn=978-0-87630-964-3|pages=260–}}</ref><ref name="WyattChew2008">{{cite book| vauthors = Wyatt RJ, Chew RH |title=Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use|url=https://books.google.com/books?id=4ZUikjcnM2QC&pg=PA142|date=20 May 2008|publisher=American Psychiatric Pub|isbn=978-1-58562-687-8|pages=142–}}</ref><ref name="FortinashWorret2014">{{cite book| vauthors = Fortinash KM, Worret PA |title=Psychiatric Mental Health Nursing - E-Book|url=https://books.google.com/books?id=xx8PDQAAQBAJ&pg=PA572|date=13 June 2014|publisher=Elsevier Health Sciences|isbn=978-0-323-29327-3|pages=572–}}</ref> The [[dorsogluteal]] site is recommended.<ref name="PagliaroPagliaro1999" /> A 3.75-cm (1.5-inch), 21-gauge needle is generally used, but [[obesity|obese]] individuals may require a 6.5-cm (2.5-inch) needle to ensure that the drug is indeed injected intramuscularly and not subcutaneously.<ref name="PagliaroPagliaro1999" /> Haloperidol decanoate is provided in the form of 50 or 100&nbsp;mg/mL [[oil solution]] of [[sesame oil]] and [[benzyl alcohol]] in [[ampoule]]s or [[pre-filled syringe]]s.<ref name="PagliaroPagliaro1999" /><ref name="WyattChew2008" /><ref name="LeeDesai2007">{{cite book| vauthors = Lee M, Desai A |title=Gibaldi's Drug Delivery Systems in Pharmaceutical Care|url=https://books.google.com/books?id=v0rLyVSc8EYC&pg=PA281|year=2007|publisher=ASHP|isbn=978-1-58528-136-7|pages=281–}}</ref> Its [[elimination half-life]] after multiple doses is 21&nbsp;days.<ref name="pmid7520856">{{cite journal | vauthors = Davis JM, Matalon L, Watanabe MD, Blake L, Metalon L | title = Depot antipsychotic drugs. Place in therapy | journal = Drugs | volume = 47 | issue = 5 | pages = 741–773 | date = May 1994 | pmid = 7520856 | doi = 10.2165/00003495-199447050-00004 | s2cid = 46962898 }}</ref><ref name="ZuidemaPieters1988">{{cite journal| vauthors = Zuidema J, Pieters FA, Duchateau GS |title=Release and absorption rate aspects of intramuscularly injected pharmaceuticals|journal=International Journal of Pharmaceutics|volume=47|issue=1–3|year=1988|pages=1–12|issn=0378-5173|doi=10.1016/0378-5173(88)90209-8}}</ref> The medication is marketed in many countries throughout the world.<ref name="IndexNominum2000" /><ref name="Drugs.com">{{Cite web|url=https://www.drugs.com/international/haloperidol.html|title = Haloperidol Uses, Side Effects & Warnings}}</ref>

{{Pharmacokinetics of long-acting injectable antipsychotics}}

== See also ==
* [[List of antipsychotics#Antipsychotic esters|List of antipsychotics § Antipsychotic esters]]

== References ==
{{Reflist}}

{{Antipsychotics}}
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[[Category:4-Phenylpiperidines]]
[[Category:Antipsychotic esters]]
[[Category:Butyrophenone antipsychotics]]
[[Category:4-Chlorophenyl compounds]]
[[Category:Decanoate esters]]
[[Category:4-Fluorophenyl compounds]]
[[Category:Drugs developed by Johnson & Johnson]]
[[Category:Janssen Pharmaceutica]]
[[Category:NMDA receptor antagonists]]
[[Category:Prodrugs]]
[[Category:Prolactin releasers]]
[[Category:Suspected embryotoxicants]]
[[Category:Suspected fetotoxicants]]
[[Category:Tertiary alcohols]]
[[Category:Typical antipsychotics]]

{{Psychoactive-stub}}