XK (protein)
(Redirected from XK antigen system)
Template:Short description Template:Protein
XK (also known as Kell blood group precursor) is a protein found on human red blood cells and other tissues which is responsible for the Kx antigen which helps determine a person's blood type.
Clinical significance
The Kx antigen plays a role in matching blood for blood transfusions.Script error: No such module "Unsubst".
Mutation of XK protein may lead to McLeod syndrome,[1] a multi-system disorder characterized by hemolytic anemia, myopathy, acanthocytosis, and chorea.[2]
XK is located on the X chromosome (cytogenetic band Xp21.1) and absence of the XK protein is an X-linked disease.[3]
Function
XK is a membrane transport protein of unknown action.[4]
References
External links
- GeneReviews/NCBI/NIH/UW entry on McLeod Neuroacanthocytosis Syndrome
- XK at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
- Template:MeshName
Script error: No such module "Navbox".