2β-Propanoyl-3β-(2-naphthyl)-tropane
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2β-Propanoyl-3β-(2-naphthyl)-tropane or WF-23 (Wake Forest-23, named after the university where it was first created) is a cocaine analogue. It is several hundred times more potent than cocaine at being a serotonin-norepinephrine-dopamine reuptake inhibitor.[1]
As can be seen on PubMed, these acyl substituted phenyltropanes are highly potent MAT inhibitors and also have a very long half-life, spanning perhaps at least a few days;[2][3] as the half-life of the dopamine transporter in rats was found to be 2–3 days under normal conditions (with agonists, antagonists, and transporter inhibitors altering the half-life),[4] it may be that WF-23 largely or mostly binds to its transporters until they are degraded.
See also
References
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- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Davies HM, Childers SR, Bennett B, "Process for blocking 5-HT and dopamine uptake with biologically active tropane derivatives", issued Script error: No such module "auto date formatter"., assigned to Wake Forest University Health SciencesScript error: No such module "Check for unknown parameters".
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Further reading
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