Vesicle-associated membrane protein 8

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Template:Short description Template:Cs1 config Template:Infobox gene Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.[1][2][3]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.[3] Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.[4]

Interactions

Vesicle-associated membrane protein 8 has been shown to interact with STX4,[5][6] SNAP23,[5][7] STX1A,[8] STX8[9] and STX7.[9][10]

References

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Further reading

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