Bisoctrizole
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| Template:Longitem | C41H50N6O2 |
| Molar mass | 658.88 g/mol |
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Bisoctrizole (INN[1]/USAN,[2] marketed by BASF as Tinosorb M, by DSM Nutritional Products as Parsol Max, by Everlight Chemical as Eversorb M, and by MPI as Milestab 360, INCI methylene bis-benzotriazolyl tetramethylbutylphenol) is a phenolic benzotriazole that is added to sunscreens to absorb UV rays.[3] It is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays.[3] It also reflects and scatters UV.Template:Fact
Bisoctrizole is what is termed is a hybrid UV absorber, which has been described as an organic UV filter produced in microfine organic particles (< 200 nm),Script error: No such module "Unsubst".[4]Template:Better source[5]Template:Primary source inline like microfine zinc oxide and titanium dioxide.Script error: No such module "Unsubst".Template:Fact Where other organic UV absorbers dissolved in either the oily or aqueous phases, bisoctrizole dissolves poorly in both.Template:Fact
Hence, bisoctrizole is formulated in sunscreen preparations as a 50% suspension, the absorber added to the water phase,Template:Contradict-inline and mineral micropigments usually added to the oil phase.Template:Fact The bisoctrizole particles are stabilized by the surfactant decyl glucoside.Template:Fact The compound shows very little photodegradation, and has a stabilizing effect on other UV absorbers, octyl methoxycinnamate (octinoxate) in particular.Template:Fact
In primary research reports, bisoctrizole has been reported to minimally penetrate skin,[6]Template:Primary source inline and has been described as lacking estrogenic effects in vitro.[7]Template:Primary source inline
Bisoctrizole has not yet been approved by the U.S. Food and Drug Administration (FDA),Template:Fact but is approved in the EU and other parts of the world.[8]Template:Better source[9][10]Template:Full
References
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External links
- Ciba® TINOSORB® M – Microfine UV absorber with Triple Action
- http://www.dermatologytimes.com/dermatologytimes/article/articleDetail.jsp?id=159652
- NEW-WAVE SUNSCREENS – Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions, C&EN Cover Story
- fda.gov