Amfepramone
Template:Short description Script error: No such module "redirect hatnote". Template:Use dmy dates Template:Main other <templatestyles src="Infobox drug/styles.css"/> Script error: No such module "Infobox".Template:Template otherScript error: No such module "TemplatePar".{{Infobox drug/maintenance categoriesTemplate:Yesno | drug_name = | INN = | _drugtype =
| _has_physiological_data= | _has_gene_therapy=
| vaccine_type= | mab_type= | _number_of_combo_chemicals=Script error: No such module "ParameterCount". | _vaccine_data= | _mab_data= | _mab_vaccine_data= | _mab_other_data=131911O=C(c1ccccc1)C(N(CC)CC)CRacemic mixture1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3XXEPPPIWZFICOJ-UHFFFAOYSA-NTemplate:StdinchiciteTemplate:Stdinchicite | _combo_data= | _physiological_data= | _clinical_data=Template:Drugs.coma682037Diethylpropion B2By mouthTenuate, Tepanil, Nobesine, othersA08 | _legal_data=S4[1]B2[2][3]Schedule G (CDSA IV)Prescription only (Anlage III for higher doses)[4][5]Rx-onlyClass C[6]Schedule IV
| _other_data=(RS)-2-diethylamino-1-phenylpropan-1-one
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| _datapage = Amfepramone (data page) | _vaccine_target=_type_not_vaccine | _legal_all=S4B2Schedule G (CDSA IV)Class CSchedule IVRx-only | _ATC_prefix_supplemental=A08 | _has_EMA_link = | CAS_number=90-84-6 | PubChem=7029 | ChemSpiderID=6762 | ChEBI=4530 | ChEMBL=1194666 | DrugBank=DB00937 | KEGG=D07444 | _hasInChI_or_Key=yes | UNII=Q94YYU22B8 | _hasJmol02 = |_hasMultipleCASnumbers = |_hasMultiplePubChemCIDs = |_hasMultipleChEBIs =
| _countSecondIDs=Script error: No such module "ParameterCount". | _countIndexlabels=Script error: No such module "ParameterCount". | _trackListSortletter= |QID = |QID2 = |Verifiedfields=changed |Watchedfields= |verifiedrevid=456687601}} Amfepramone, also known as diethylpropion, is a stimulant drug of the phenethylamine, amphetamine, and cathinone classes that is used as an appetite suppressant.[7][8] It is used in the short-term management of obesity, along with dietary and lifestyle changes.[7] Amfepramone has a similar chemical structure to the antidepressant and smoking cessation aid bupropion (previously called amfebutamone), which has also been developed as a weight-loss medicine when in a combination product with naltrexone.[9]
Pharmacology
Amfepramone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone.[10] Ethcathinone (and therefore amfepramone as well) is a very weak dopaminergic and serotonergic, and is approximately 10× and 20× stronger on norepinephrine in comparison, respectively.[10]
Chemistry
Amfepramone can be synthesized from propiophenone by bromination, followed by reaction with diethylamine.[11][12]
Society and culture
Names
Another medically utilized name is diethylpropion (British Approved Name (BAN) and Australian Approved Name (AAN)). Chemical names include: α-methyl-β-keto-N,N-diethylphenethylamine, N,N-diethyl-β-ketoamphetamine and N,N-diethylcathinone. Brand names include: Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil and Tenuate.
Legal status
Amfepramone is classified as a Schedule IV controlled substance in the United States. In the UK amfepramone is a class C drug [13] and as a medicine, it is a Schedule 3 Controlled Drug which requires safe custody.
As of June 2022, the safety committee of the European Medicines Agency (EMA) recommends the withdrawal of marketing authorizations for amfepramone.[14][5]
Recreational use
The authors of several studies of amfepramone claim that the substance has a relatively low potential for causing addiction in users.[15][16][6][17]
References
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