Suplatast tosilate
(Redirected from Suplatast)
Template:Short description Template:Drugbox Suplatast tosilate (INN) is an inhibitor of cytokine T helper cells.[1] Overstimulation of these Th2 cells can lead to an allergic reaction,[2] so the drug is used as an antihistamine.[3] It has also been used in the treatment of Kimura's disease.[4][5]
Synthesis
Acylation of 1-(4-aminophenoxy)-3-ethoxypropan-2-ol (1) with 3-methylthiopropionyl chloride (2) gives the amide (3). Methylation of the thioether using methyl tosylate (4) yields suplatast as its toluenesulfonic acid salt.[6][7][8]
References
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- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Akihide Koda, et al., "Sulfonium compounds, processes for preparing the compounds and pharmacological composiitons containing the same", issued Script error: No such module "auto date formatter"., assigned to Taiho Pharmaceutical Co LtdScript error: No such module "Check for unknown parameters".
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Further reading
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