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...[[Reverse-transcriptase inhibitor#Nucleotide analog reverse-transcriptase inhibitors .28NtARTIs or NtRTIs.29|NtRTIs]]''' | '''[[Reverse-transcriptase inhibitor#Non-nucleoside reverse-transcriptase inhibitors .28NNRTIs.29|NNRTI]]''' ...

...ovir comparison.svg|thumb|The [[antiviral drug]] [[aciclovir]] (bottom), a nucleoside analogue that functions by mimicking [[guanosine]] (top)]] ...r chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold. |journal=Antiviral Research |date=June 2018 |volume=154 |pages=66 ...

...[[hepatitis B]]. RTIs [[Enzyme inhibition|inhibit]] activity of [[reverse transcriptase]], a viral [[DNA polymerase]] that is required for replication of HIV and o ...transcription and translation, to reproduce the virus. RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stra ...

...tor|enzyme inhibition]] that occurs when an [[enzyme]] binds a [[substrate analog]] and forms an irreversible complex with it through a covalent bond during Some clinical examples of suicide inhibitors include: ...

...reverse transcriptase inhibitor]] and works by blocking the [[HIV reverse transcriptase]] and hepatitis B virus polymerase.<ref name=AHFS2016/> ...level resistance is associated with the M184V/I mutation in the [[reverse transcriptase]] gene as reported by Raymond Schinazi's group at [[Emory University]]. [[G ...

...'''ddC'''), also called dideoxycytidine, is a nucleoside analog [[reverse-transcriptase inhibitor]] (NRTI) sold under the trade name '''Hivid'''. Zalcitabine was t Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated wit ...

...dine is in the [[Reverse-transcriptase inhibitor|nucleoside analog reverse-transcriptase inhibitor]] (NRTI) class of medication.<ref name=AHFS2016/> ...ompeting with the natural substrate, [[thymidine triphosphate]]. [[Reverse transcriptase]] is the enzyme the virus uses to make a DNA copy of its RNA in order to in ...

...f [[highly active antiretroviral therapy]] (HAART). It is of the [[reverse-transcriptase inhibitor]] class. ...t acts as a chain terminator by incorporation and inhibits viral [[reverse transcriptase]] by competing with natural [[Adenosine triphosphate|dATP]]. ...

...me '''Emtriva''' (formerly '''Coviracil'''), is a [[nucleoside]] [[reverse-transcriptase inhibitor]] (NRTI) for the prevention and treatment of [[HIV]] infection in ...mistry)|analogue]] of [[cytidine]]. The drug works by inhibiting [[reverse transcriptase]], the enzyme that copies HIV RNA into new viral DNA. By interfering with t ...

...> It prevents the hepatitis B virus from multiplying by blocking [[reverse transcriptase]].<ref name=AHFS2016/> ...ion (genetics)|transcription]] in the [[viral replication]] process. Other nucleoside and nucleotide analogues include [[lamivudine]], [[telbivudine]], [[adefovi ...

...11-09|df=dmy-all }}</ref> Similar to other [[nucleoside analog]] [[reverse-transcriptase inhibitor]]s (NRTIs), abacavir is used together with other [[HIV medication ...-09|df=dmy-all }}</ref> Within the NRTI class, abacavir is a [[carbocyclic nucleoside]].<ref name=AHFS2015/> ...

[[entry inhibitors]] – [[integrase inhibitors]] – ...

...me=AHFS2016/> It is a [[Reverse-transcriptase inhibitor|nucleotide reverse transcriptase inhibitor]] and works by decreasing the ability of the viruses to replicate ...eral neuropathy|neuropathy]]. Tenofovir also interacts with HIV-1 protease inhibitors such as [[atazanavir]], by decreasing atazanavir concentrations while incre ...

...class.<ref name=AHFS2016/> It works by inhibiting the [[enzyme]] [[reverse transcriptase]] that HIV uses to make DNA and therefore decreases replication of the viru ...AHFS2016/><ref>{{cite book | vauthors = Reeves JD, Derdeyn CA |title=Entry Inhibitors in HIV Therapy |date=2007 |publisher=Springer Science & Business Media |isb ...

{{Distinguish|nucleoside|nucleobase}} ...amental, cellular level. They provide chemical energy—in the form of the [[nucleoside triphosphate]]s, [[adenosine triphosphate]] (ATP), [[guanosine triphosphate ...

...tfeeding/acyclovir.html|archive-date=5 March 2016}}</ref> Aciclovir is a [[nucleoside analogue]] that mimics [[guanosine]].<ref name=AHFS2015/> It works by decre ...hors = Piret J, Boivin G | title = Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management | journal = Antimicrobial ...

...) or integrase inhibitors (also known as integrase nuclear strand transfer inhibitors or INSTIs) as a "base".<ref name=":0">{{Cite web |title = Guidelines for th ===Entry inhibitors=== ...

...ue reverse transcriptase inhibitor|nucleoside analog reverse transcriptase inhibitors]] (NRTIs) |[[Reverse transcription polymerase chain reaction|rRT-PCR testing]] ...

...isoenzymes have different reaction kinetics and are inhibited by different inhibitors. ...a complementary DNA molecule (or an RNA molecule in the case of [[reverse transcriptase]], an enzyme present in [[retrovirus]]). ...