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[[Category:Farnesyl pyrophosphate synthase inhibitors]] ...

[[Category:Farnesyl pyrophosphate synthase inhibitors]] ...

...[Farnesyl pyrophosphate|farnesyl diphosphate]] (FPP), and [[Geranylgeranyl pyrophosphate|geranylgeranyl diphosphate]] (GGPP) via the [[mevalonate pathway]]. These i [[Category:Farnesyl pyrophosphate synthase inhibitors]] ...

...''1''') is oxidized to '''2''' by [[Delta-cadinene synthase|(+)-δ-cadinene synthase]]. The [[cadinene|(+)-δ-cadinene]] ('''2''') is involved in making the basi [[Category:Aldehyde dehydrogenase inhibitors]] ...

...phate, bisphosphonates inhibit the growth and dissolution of bone. Unlike pyrophosphate, bis(phosphonates) are very stable in aqueous solution. They resist break ...ucture of pyrophosphate, it can inhibit activation of enzymes that utilize pyrophosphate. ...

...ear = 1989 | title = Primary structure of four allatostatins: Neuropeptide inhibitors of juvenile hormone biosynthesis | journal = Proceedings of the National Ac ...hase]] takes one DMAPP and two IPP to give the C₁₅ metabolite [[farnesyl diphosphate]]. There are a large number of additional steps to generate cho ...

...yrophosphate]]. The first step is controlled by the enzyme [[germacrene B synthase]]. In the second step, the C(8) position is easily activated for an allyli [[Category:Hydrolase inhibitors]] ...

[[Category:Farnesyl pyrophosphate synthase inhibitors]] ...

* [[Steroidogenesis inhibitors]] (exogenous), such as [[alfatradiol]], which suppress steroid synthesis fo ...e]] (PP or IPP) and [[dimethylallyl pyrophosphate]] (DMAPP) form [[geranyl pyrophosphate]] (GPP), [[squalene]] and [[lanosterol]] (which can be converted into other ...

Mevalonate is finally converted to [[isopentenyl pyrophosphate]] (IPP) through two phosphorylation steps and one decarboxylation step that Three molecules of isopentenyl pyrophosphate condense to form [[farnesyl pyrophosphate]] through the action of geranyl transferase. ...

...5-carbon precursors ([[Isopentenyl pyrophosphate|IPP]] or [[Dimethylallyl pyrophosphate|DMAPP]]), as occurs in other sesquiterpene biosynthetic systems. The routes ...ngineered to express the enzyme [[Amorpha-4,11-diene synthase|amorphadiene synthase]] and a [[cytochrome P450]] [[monooxygenase]] (CYP71AV1), both from ''[[Art ...