5-Methyluridine
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| Template:Longitem | C10H14N2O6 |
| Molar mass | 258.23 g/mol |
| Density | 1,6 g/cm3[1] |
| Melting point | Template:Chembox CalcTemperatures |
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The chemical compound 5-methyluridine (symbol m5U), also called ribothymidine (rT)[footnote 1]Template:R/superscript, is a pyrimidine nucleoside. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar.[4] It is a white solid.
m5U is one of the most common modifications made to cellular RNA. It almost universally occurs in position 54 (part of the T arm) of eukaryotic and bacterial tRNA, serving to stabilize the molecule. The same "T-loop" motif occurs in many other forms of noncoding RNA such as tmRNA and rRNA. Loss of the tRNA modification does not usually produce a different, less fit, phenotype.[5]
See also
Footnotes
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