Pure red cell aplasia
Template:Use dmy dates Template:Infobox medical condition (new) Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922.[1]
Signs and symptoms
Signs and symptoms may include:
- Pale appearance
- Rapid heart rate
- Fatigue
Causes
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Diagnosis
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Treatment
PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as cyclosporin in many patients,[9] though this approach is not without risk.[10]
It has also been shown to respond to treatments with rituximab and tacrolimus.Script error: No such module "Unsubst".
For cases related to B19 parvovirus, administration of commercial immunoglobulin can treat or cure parvovirus by replacing neutralizing antibodies.[11]
See also
- Diamond–Blackfan anemia (genetic red cell aplasia)
- Aplastic anemia (aplasia affecting other bone marrow cells as well)
References
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- ↑ Petrochko C (2009). "FDA Strengthens Warning on Transplant Drug." Medpage Today. 14 August 2009. Accessed 19 August 2009.
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- ↑ Online Mendelian Inheritance in Man (OMIM): 105650
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- ↑ National Organization for Rare Disorders. (2003). Nord Guide to Rare Disorders. Lippincott Williams & Wilkins.
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