Dornase alfa
(Redirected from Pulmozyme)
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Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis.[1] It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.[1] Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions.[1] It is produced in Chinese hamster ovary cells.[1]
Medical uses
Dornase alfa is indicated for the management of people with cystic fibrosis to improve pulmonary function.[1]
Society and culture
Legal status
Dornase alfa is an orphan drug.[2]
Research
Dornase alfa has been shown to improve lung function in non-cystic fibrosis pre-term infants atelectasis.[3][4]