P57 (glycoside)
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P57 is an oxypregnane steroidal glycoside isolated from the traditional African medicine Hoodia gordonii. P57 is hypothesized to be the chemical constituent responsible for the putative appetite suppressant activity of Hoodia.[1][2][3]
In a study on rats at Brown Medical School, intracerebroventricular injections of the purified P57 demonstrated that the compound has a likely central nervous system (CNS) mechanism of action like that of neuroactive steroids. [4] The studies demonstrated that the compound increases the content of ATP by 50-150% in hypothalamic neurons. In addition, third ventricle administration of P57 reduced subsequent 24-hour food intake by 40-60%.
See also
- Anorectic, for additional information about appetite suppressants
- Neuroactive steroid
References
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