Methylarginine
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| Template:Longitem | 2262067 (R) |
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| MeSH | omega-N-Methylarginine |
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| Molar mass | Template:Chem molar mass |
| log P | −0.63 |
| Acidity (pKa) | 2.512 |
| Basicity (pKb) | 11.488 |
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N-Methylarginine is an inhibitor of nitric oxide synthase.[1][2] Chemically, it is a methyl derivative of the amino acid arginine. It is used as a biochemical tool in the study of physiological role of nitric oxide.
The inhibiting effect of N-methylarginine on vasodilation is lower in hypertensive patients than in normal subjects, indicating endothelial dysfunction.[3] The inhibiting effect of N-methylarginine on vasodilation declines progressively with age, but has been restored with vitamin C in the oldest subjects.[3]
See also
References
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