Mir-BHRF1-1 microRNA precursor family
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The mir-BHRF1-1 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus) and Cercopithicine herpesvirus 15. In Epstein–Barr virus, mir-BHRF1-1 is found in the 5' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-2 and Mir-BHRF1-3.[1]
BHRF-1-1 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein–Barr virus genome.[2] BHRF-1-1 has been shown to be expressed in latency-III infected lymphoblasts.[3]
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