Melanocortin 3 receptor
Template:Short description Template:Infobox gene Melanocortin 3 receptor (MC3R) is a protein that in humans is encoded by the MC3R gene.[1][2]
Function
This gene encodes MC3R, a G-protein coupled receptor (GPCR) for melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) that is expressed in the brain.
MC3R regulates the timing of sexual maturation, the rate of linear growth and the accrual of lean mass, which are all energy-sensitive processes. Humans who carry loss-of-function mutations in MC3R have a later onset of puberty. [3]
Research
Studies performed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), found that two specific polymorphisms in the MC3R gene may be associated with pediatric obesity and greater body mass because of greater energy intake. Children who were homozygous for C17A + G241A consumed approximately 38% more than those who did not contain aforementioned polymorphisms. The study concluded that these genetic variants did not affect energy expenditure.[4]
Ligands
- Ac-Val-Gln-(pI)DPhe-DTic-NH2, first MC3 selective agonist, 100x selectivity over MC4.[5]
- Ac-Val-Gln-DBip-DTic-NH2, 140x selectivity over MC4.[6]
- Pyrrolidine bis-cyclic guanidines, non-peptide small molecule MC3 agonists, good selectivity over MC4 but not over MC1 or MC5.[7]
- SHU-9119, mixed MC3/MC4 antagonist.[8]
Evolution
Paralogue
Source:[9]
- MC5R
- MC4R
- MC1R
- MC2R
- LPAR1
- S1PR2
- GPR12
- S1PR1
- GPR6
- LPAR2
- S1PR3
- GPR3
- GPR119
- CNR1
- LPAR3
- S1PR5
- S1PR4
- CNR2
See also
References
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- ↑ Lam, B.Y.H., Williamson, A., Finer, S. et al. MC3R links nutritional state to childhood growth and the timing of puberty. Nature (2021). Script error: No such module "CS1 identifiers".
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Further reading
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External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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