Benazepril
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Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[1] It is a reasonable initial treatment for high blood pressure.[1] It is taken by mouth.[1] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.[1]
Common side effects include feeling tired, dizziness, cough, and light-headedness with standing.[1] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema.[1] Use in pregnancy may harm the baby, while use when breastfeeding may be safe.[2] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[1]
Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication.[1] In 2022, it was the 159th most commonly prescribed medication in the United States, with more than 3Script error: No such module "String".million prescriptions.[3][4]
Medical uses
Lotensin is indicated for the treatment of hypertension, to lower blood pressure.[5][1]
Side effects
The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated.[6]
Contraindications
Benazepril can harm the fetus.[7]
Dosage forms
It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).
Veterinary uses
Under the brand names Fortekor (Novartis)[8] and VetACE (Jurox Animal Health),[9] benazepril is used to treat congestive heart failure in dogs[10][11] and chronic kidney failure in cats and dogs.[12]
References
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