Liver kidney microsomal type 1 antibody

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File:LKM1 ANTIBODIES.jpg
Immunofluorescence pattern of LKM1 antibodies on liver (left) and kidney (right). Staining of proximal tubules can be observerved on the kidney, whereas distal tubules remain unstained.

Liver kidney microsomal type 1 antibody (anti-LKM1) is an autoantibody associated with autoimmune hepatitis (AIH).[1] Specifically, its presence in AIH defines type 2 AIH,[2][3] although it has been proposed that anti-liver cytosol type 1 autoantibody without detectable anti-LKM1 can be seen in type 2 AIH.[4] It is one of the several subtypes of anti–liver-kidney microsome antibodies that are known. The frequent association of anti-LKM-1 antibodies and hepatitis C virus (HCV) infections and the probable existence of an infection-associated autoimmune form of anti-LKM-1-associated hepatitis, requiring a different therapeutic strategy, necessitate the exact determination of anti-LKM-1 specificities.[3][5][6]

See also

References

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