Arachidonate 5-lipoxygenase inhibitor
Template:Short description Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukotrienes is a major cause of inflammation in asthma, allergic rhinitis, and osteoarthritis.[1][2]
Examples of 5-LOX inhibitors include the pharmaceutical drugs meclofenamate sodium, zileuton[3][4] and the natural products myxochelins/pseudochelin[5][6] as well as nordihydroguaiaretic acid (NDGA).[7]
Some chemicals found in trace amounts in food, as well as some dietary supplements, have been shown to inhibit 5-LOX; these include baicalein, caffeic acid, curcumin,[3] hyperforin and St John's wort.[8][9][10]
Acetyl-keto-beta-boswellic acid (AKBA), one of the bioactive boswellic acids found in Boswellia serrata (Indian Frankincense) has been found to inhibit 5-lipoxygenase strongly as an allosteric inhibitor.[7] Boswellia administration has been shown to reduce brain edema in patients irradiated for brain tumor and it is believed to be due to 5-lipoxygenase inhibition.[11][12]
See also
References
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- ↑ David L. Nelson, Michael M. Cox. Lehninger's Principles of Biochemistry, Fifth Edition. W.H. Freeman and Co., 2008, p. 359.
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1. Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes ...
2. Prostaglandin G/H synthase 1 ... General function: Involved in peroxidase activity - ↑ Script error: No such module "Citation/CS1".
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External links
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