Interleukin-7 receptor
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The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).[1][2] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15.[3] Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.
Function
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombinationScript error: No such module "Unsubst".. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation Script error: No such module "Unsubst".. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[4]
Diseases
Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia,[5] multiple sclerosis,[6] rheumatoid arthritis and juvenile idiopathic arthritis.[7]
See also
References
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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