Gag/pol translational readthrough site
Gag/pol translational readthrough site (or Retroviral readthrough element) is a cis-regulatory element found in retroviruses.[1] The readthrough site facilitates the mechanism of translation readthrough of the stop codon at the gag-pol junction producing the gag and pol fusion protein in certain retroviruses. Retroviruses whose gag and pol genes are in the same reading frame often depend upon approximately 5% read-through of the gag UAG termination codon to form the gag-pol polyprotein. This readthrough is usually dependent on a pseudoknot located eight nucleotides downstream of the stop codon (UAG). Sequence conservation is found in the second pseudoknot loop.
![GP_knot1[2]](/wiki143/index.php?title=File:GP_knot1_secondary_structure.jpg){kind=link}
![GP_knot2[3]](/wiki143/index.php?title=File:GP_knot2_secondary_structure.jpg){kind=link}
References
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