Alvocidib
Alvocidib (INN; also known as flavopiridol) is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development by Tolero Pharmaceuticals for the treatment of acute myeloid leukemia. It has been studied also for the treatment of arthritis[1] and atherosclerotic plaque formation.[2] The target of alvocidib is the positive transcription elongation factor P-TEFb.[3][4] Treatment of cells with alvocidib leads to inhibition of P-TEFb and the loss of mRNA production.[5][6]
The compound is a synthetic analog of natural product rohitukine which was initially extracted from Aphanamixis polystachya (formerly Amoora rohituka, hence the name) and later from Dysoxylum binectariferum.[7][8]
Orphan drug
The FDA has granted orphan drug designation to alvocidib for the treatment of patients with acute myeloid leukemia.[9]
References
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